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Rough Endoplasmic Reticulum
They are a continuous series of membrane-bound flattened sacs within the cell's cytoplasm. They have a rough outer appearance because of the protein-synthesizing particles called ribosomes on them.
__Smooth Endoplasmic Reticulum __
They are a meshwork of fine disklike tubular membrane vesicles within the cell's cytoplasm. They are involved in synthesizing and storing lipids, including cholesterol and phospholipids.
The ribosome is a cytoplasmic structure that is minute and sphere-shaped. It is composed of protein and ribonucleic acid (RNA). They serve as the site of protein synthesis.